PPP1R13L Gene Summary [Human]
IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | PPP1R13L |
| Official Name | protein phosphatase 1 regulatory subunit 13 like [Source:HGNC Symbol;Acc:HGNC:18838] |
| Ensembl ID | ENSG00000104881 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1 regulatory subunit 13 like, RelA-associated Inhibitor |
| Synonyms | ARCME, AV260376, BE289038, CMAEA, IASPP, NKIP1, protein phosphatase 1 regulatory subunit 13 like, protein phosphatase 1, regulatory subunit 13 like, RAI, RAI4, wa3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP1R13L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- transcription co-repressor
- Ankyrin repeats (3 copies)
- protein binding
- identical protein binding
- Ankyrin repeat
- Src Homology 3 domain superfamily
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute leukemia
- neoplasia
- tumorigenesis
- arrhythmogenic cardiomyopathy with variable ectodermal abnormalities
- primary dilated cardiomyopathy
- ventricular tachycardia
- type M6 acute myeloid leukemia
- cardiomyopathy
- cardiac fibrosis
- ventricular extrasystole
role in cell
- production in
- expression in
- proliferation
- differentiation
- quantity
- apoptosis
- consumption in
- survival
- abnormal morphology
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cell junction
- Cytoplasm
- cytoplasmic bridges
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP1R13L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- embryonic camera-type eye development
- negative regulation of inflammatory response
- post-embryonic development
- positive regulation of cell differentiation
- cardiac muscle contraction
- hair cycle
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- cardiac right ventricle morphogenesis
- ventricular cardiac muscle tissue development
- apoptotic process
- multicellular organismal homeostasis
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- cytosol
- cell junction
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- transcription corepressor activity
- cadherin binding