DKKL1
DKKL1 Gene Summary
The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Details
| Type | Protein Coding |
| Official Symbol | DKKL1 |
| Official Name | dickkopf like acrosomal protein 1 [Source:HGNC Symbol;Acc:HGNC:16528] |
| Ensembl ID | ENSG00000104901 |
| Bio databases IDs | |
| Aliases | dickkopf like acrosomal protein 1, cancer/testis antigen 34, soggy |
| Synonyms | CT34,dickkopf-like 1,dickkopf like acrosomal protein 1,mSgy,RGD1563523,SGY,SGY-1,Soggy,Soggy-1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Pathways
Biological processes and signaling networks where the DKKL1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ITIH2
- TMEM59
- NHLRC2
- PCDHGA11
- LTN1
- RPTOR
- AFG2B
- MMP14
- PRMT9
- PCSK1N
disease
- multiple sclerosis
regulated by
- IL2
- WNT3A
- EGR3
- EGR2
- embryonic stem cells
- FIGLA
regulates
- testosterone
role in cell
- apoptosis
- differentiation
- penetration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the DKKL1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- penetration of zona pellucida
- positive regulation of apoptotic process
- positive regulation of fat cell differentiation
- canonical Wnt receptor signaling pathway
- anatomical structure morphogenesis
- negative regulation of testosterone biosynthetic process
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- acrosomal vesicle
MOLECULAR FUNCTION
What the gene product does at the molecular level
- receptor antagonist activity