LTN1 Gene Summary [Human]
Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | LTN1 |
| Official Name | listerin E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:13082] |
| Ensembl ID | ENSG00000198862 |
| Bio databases IDs | |
| Aliases | listerin E3 ubiquitin protein ligase 1, listerin |
| Synonyms | 4930528H02Rik, C21orf10, C21orf98, Listerin, listerin E3 ubiquitin protein ligase 1, RNF160, Zfp294, ZNF294 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LTN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ring finger
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- enzyme
- Ring finger domain
- protein binding
- FANCL C-terminal domain
- RING-H2 zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- ribosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LTN1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rescue of stalled ribosome
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- cytosolic ribosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- ribosomal large subunit binding