Dkkl1 Gene Summary [Mouse]
Predicted to enable co-receptor binding activity and receptor antagonist activity. Involved in negative regulation of testosterone biosynthetic process; penetration of zona pellucida; and positive regulation of apoptotic process. Acts upstream of or within canonical Wnt signaling pathway and positive regulation of fat cell differentiation. Located in acrosomal vesicle. Is expressed in several structures, including dorsal root ganglion; extraembryonic component; reproductive system; and sensory organ. Orthologous to human DKKL1 (dickkopf like acrosomal protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dkkl1 |
| Official Name | dickkopf-like 1 [Source:MGI Symbol;Acc:MGI:1354963] |
| Ensembl ID | ENSMUSG00000030792 |
| Bio databases IDs | |
| Aliases | dickkopf-like 1 |
| Synonyms | CT34, dickkopf-like 1, dickkopf like acrosomal protein 1, mSgy, RGD1563523, SGY, SGY-1, Soggy, Soggy-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dkkl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Pathways
Biological processes and signaling networks where the Dkkl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dkkl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- penetration of zona pellucida
- positive regulation of apoptotic process
- positive regulation of fat cell differentiation
- canonical Wnt receptor signaling pathway
- anatomical structure morphogenesis
- negative regulation of testosterone biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- acrosomal vesicle
Molecular Function
What the gene product does at the molecular level
- receptor antagonist activity