MORF4L2 Gene Summary [Human]
Predicted to be involved in heterochromatin assembly and histone modification. Predicted to act upstream of or within positive regulation of striated muscle cell differentiation and positive regulation of transcription by RNA polymerase II. Located in nucleolus; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MORF4L2 |
| Official Name | mortality factor 4 like 2 [Source:HGNC Symbol;Acc:HGNC:16849] |
| Ensembl ID | ENSG00000123562 |
| Bio databases IDs | |
| Aliases | mortality factor 4 like 2, MORF-related gene X |
| Synonyms | 2410017O14Rik, KIAA0026, LOC100045126, LRRG00119, mKIAA0026, MORFL2, mortality factor 4 like 2, MRGX, Sid393p |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MORF4L2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- male-specific lethal-3 similarity domain
- nuclear localization sequence
- leucine zipper domain
- protein binding
- helix-loop-helix domain
- MRG
- ATP/GTP binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- growth
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- Plasma Membrane
- nucleosomes
- nucleoplasm
- nucleoli
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MORF4L2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- regulation of double-strand break repair
- positive regulation of transcription, DNA-dependent
- regulation of apoptotic process
- regulation of cell cycle
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- NuA4 histone acetyltransferase complex
- nucleosome
- nucleolus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding