RBM25 Gene Summary [Human]
Enables mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome and regulation of apoptotic process. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RBM25 |
| Official Name | RNA binding motif protein 25 [Source:HGNC Symbol;Acc:HGNC:23244] |
| Ensembl ID | ENSG00000119707 |
| Bio databases IDs | |
| Aliases | RNA binding motif protein 25, functional spliceosome-associated protein 94 |
| Synonyms | 2600011C06Rik, 2610015J01Rik, A130095G20Rik, AL023075, fSAP94, NET52, RED120, RNA binding motif protein 25, RNPC7, S164, Snu71, U1 small ribonucleoprotein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RBM25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- mRNA binding
- PWI, domain in splicing factors
- PWI domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- Hutchinson-Gilford progeria syndrome
- streptozotocin induced type1 diabetes
- diabetic retinopathy
- infection by HIV-1
role in cell
- expression in
- proliferation
- apoptosis
- alternative splicing by
- berzosertib resistance
- alternative splicing in
- reverse transcription in
- reverse transcription
- ceralasertib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
- nuclear granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RBM25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- regulation of alternative nuclear mRNA splicing, via spliceosome
- regulation of apoptotic process
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nuclear speck
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- mRNA binding