ICAM5 Gene Summary [Human]
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ICAM5 |
| Official Name | intercellular adhesion molecule 5 [Source:HGNC Symbol;Acc:HGNC:5348] |
| Ensembl ID | ENSG00000105376 |
| Bio databases IDs | |
| Aliases | intercellular adhesion molecule 5, telencephalin |
| Synonyms | CD50, ICAM-3, intercellular adhesion molecule 5, intercellular adhesion molecule 5, telencephalin, Telencephalin, TLCN, TLN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ICAM5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Intercellular adhesion molecule (ICAM), N-terminal domain
- cytoplasmic domain
- immunoglobulin domain
- ectodomain
- transmembrane domain
- Immunoglobulin like
- intracellular domain
- Immunoglobulin I-set domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- migraines
- eczema
- metabolic syndrome X
- hypertension
- psoriasis
- Huntington disease
- spatial memory impairment
role in cell
- phosphorylation in
- formation
- upregulation in
- expression in
- outgrowth
- density
- morphology
- phagocytosis by
- width
- retraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- somatodendritic region
- postsynaptic region
- cellular membrane
- cell-cell contacts
- uropod
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ICAM5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phagocytosis
- cell adhesion
- regulation of synapse assembly
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- integrin binding