KIF18A Gene Summary [Human]
KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008]
Details
| Type | Protein Coding |
| Official Symbol | KIF18A |
| Official Name | kinesin family member 18A [Source:HGNC Symbol;Acc:HGNC:29441] |
| Ensembl ID | ENSG00000121621 |
| Bio databases IDs | |
| Aliases | kinesin family member 18A, protein phosphatase 1, regulatory subunit 99 |
| Synonyms | B130001M12Rik, DKFZp434G2226, gcd2, KIF18, kinesin family member 18A, MS-KIF18A, PPP1R99, RGD1561740 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KIF18A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinesin motor, catalytic domain
- microtubule binding
- Myosin and Kinesin motor domain
- actin binding
- Kinesin motor domain
- microtubule plus-end binding
- plus-end-directed kinesin ATPase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rectum cancer
- lung adenocarcinoma
- hepatocellular carcinoma
- epithelial cancer
- liver cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
role in cell
- phosphorylation in
- proliferation
- apoptosis
- expression in
- migration
- cell viability
- invasion by
- formation
- formation in
- misalignment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- ruffle
- Nucleus
- cytosol
- caveolae
- kinetochore microtubule
- central spindle
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KIF18A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to estradiol stimulus
- regulation of microtubule cytoskeleton organization
- seminiferous tubule development
- male meiosis
- protein transport
- mitotic sister chromatid segregation
- microtubule-based movement
- mitotic metaphase plate congression
- microtubule depolymerization
Cellular Component
Where in the cell the gene product is active
- nucleus
- caveola
- microtubule cytoskeleton
- centrosome
- cytoplasm
- kinetochore microtubule
- ruffle
- cytosol
- kinesin complex
- kinetochore
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- tubulin-dependent ATPase activity
- actin binding
- microtubule plus-end binding
- plus-end-directed microtubule motor activity
- microtubule binding