CD69 Gene Summary [Human]
This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | CD69 |
| Official Name | CD69 molecule [Source:HGNC Symbol;Acc:HGNC:1694] |
| Ensembl ID | ENSG00000110848 |
| Bio databases IDs | |
| Aliases | CD69 molecule |
| Synonyms | AIM, BL-AC/P26, CD69 ANTIGEN, CD69 molecule, Clec2a, CLEC2C, EA1, GP32/28, MLR-3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD69 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- cytoplasmic domain
- transmembrane domain
- Lectin C-type domain
- calcium ion binding
- protein binding
- identical protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the CD69 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- insulin-dependent diabetes mellitus
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- lung cancer
- celiac disease
- chronic obstructive pulmonary disease
- Devic syndrome
- Sjögren syndrome
role in cell
- expression in
- migration
- proliferation
- production in
- differentiation
- activation in
- apoptosis
- transmembrane potential
- cytotoxicity
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD69 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to xenobiotic stimulus
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- transmembrane signaling receptor activity
- protein binding
- carbohydrate binding