CLEC11A Gene Summary [Human]
This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CLEC11A |
| Official Name | C-type lectin domain containing 11A [Source:HGNC Symbol;Acc:HGNC:10576] |
| Ensembl ID | ENSG00000105472 |
| Bio databases IDs | |
| Aliases | C-type lectin domain containing 11A |
| Synonyms | CLECSF3, C-type lectin domain containing 11A, C-type lectin domain family 11, member a, LSLCL, P47, SCF, SCGF, STEM CELL GROWTH FACTOR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLEC11A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- protein binding
- growth factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- glioblastoma
- glioblastoma cancer
- skin cancer
- sarcoidosis
- endometriosis
- septicemia
- melanoma cancer
- invasive melanoma cancer
- cutaneous melanoma cancer
role in cell
- activation
- activation in
- apoptosis
- expression in
- differentiation
- proliferation
- production in
- quantity
- migration
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- apical compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLEC11A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ossification
- signal transduction
- positive regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- carbohydrate binding