FAM83B Gene Summary [Human]
Enables epidermal growth factor receptor binding activity; phosphatidylinositol 3-kinase binding activity; and protein kinase binding activity. Involved in cell population proliferation and epidermal growth factor receptor signaling pathway. Located in cytoplasm and membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FAM83B |
| Official Name | family with sequence similarity 83 member B [Source:HGNC Symbol;Acc:HGNC:21357] |
| Ensembl ID | ENSG00000168143 |
| Bio databases IDs | |
| Aliases | family with sequence similarity 83 member B |
| Synonyms | C530008M07Rik, C6orf143, family with sequence similarity 83 member B, family with sequence similarity 83, member B, Gm516, RGD1311988 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FAM83B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphoinositide 3-kinase binding
- kinase binding
- protein kinase binding
- FAM83 A-H
- epidermal growth factor receptor binding
- PLD-like domain
- protein binding
- Catalytic domain of phospholipase D superfamily proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FAM83B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- signal transduction
- positive regulation of epidermal growth factor receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- epidermal growth factor receptor binding
- phospholipase D activity