ULK3 Gene Summary [Human]
Enables protein serine/threonine kinase activity. Involved in several processes, including fibroblast activation; protein autophosphorylation; and regulation of smoothened signaling pathway. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ULK3 |
| Official Name | unc-51 like kinase 3 [Source:HGNC Symbol;Acc:HGNC:19703] |
| Ensembl ID | ENSG00000140474 |
| Bio databases IDs | |
| Aliases | unc-51 like kinase 3 |
| Synonyms | 1200015E14Rik, DKFZp434C131, LOC686495, unc-51-like kinase 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ULK3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- MIT
- Protein tyrosine and serine/threonine kinase
- MIT domain
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Microtubule Interacting and Trafficking molecule domain
- MIT (microtubule interacting and transport) domain
- kinase domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung squamous cell carcinoma
- cervical squamous cell carcinoma
- squamous cell lung cancer
- prostate cancer
- head and neck squamous cell carcinoma
- squamous cell cervical cancer
- esophageal squamous cell cancer
- hypertension
- head and neck squamous cell cancer
role in cell
- proliferation
- expression in
- cell viability
- activation
- differentiation
- autophagy by
- binding in
- activation in
- signaling in
- dimethylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ciliary tip
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ULK3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular senescence
- response to starvation
- protein autophosphorylation
- smoothened signaling pathway
- negative regulation of smoothened signaling pathway
- mitochondrion degradation
- autophagic vacuole assembly
- piecemeal microautophagy of nucleus
- autophagy
- regulation of autophagy
- positive regulation of smoothened signaling pathway
- peptidyl-serine phosphorylation
- fibroblast activation
Cellular Component
Where in the cell the gene product is active
- pre-autophagosomal structure membrane
- cytoplasm
- pre-autophagosomal structure
- cytosol
- autophagic vacuole
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine kinase activity