JDP2 Gene Summary [Human]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | JDP2 |
| Official Name | Jun dimerization protein 2 [Source:HGNC Symbol;Acc:HGNC:17546] |
| Ensembl ID | ENSG00000140044 |
| Bio databases IDs | |
| Aliases | Jun dimerization protein 2, progesterone receptor co-activator |
| Synonyms | Jun dimerization protein 2, JUNDM2, Jundp2, TIF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human JDP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- DNA binding domain
- nucleic acid binding
- LRR-domain binding
- Basic region leucine zipper
- histone deacetylase binding
- leucine zipper domain
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- bZIP domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- basic helix-loop-helix-leucine zipper domain
- binding protein
- double-stranded DNA binding
- protein homodimerization
- bZIP
- transcription factor activity
- protein heterodimerization
- basic region leucin zipper
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- infection by bacteria
- infection by fungus
- epithelial cancer
- epithelial basal cell carcinoma
- osteopetrosis
- non-melanoma skin cancer
- skin neoplasm
- skin neoplasia
- acute myocardial infarction
role in cell
- expression in
- survival
- proliferation
- activation in
- formation
- differentiation
- abnormal morphology
- cell cycle progression
- cell spreading
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human JDP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- negative regulation of fat cell differentiation
- fat cell differentiation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- cAMP response element binding
- protein binding
- protein homodimerization activity
- histone deacetylase binding
- protein heterodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- chromatin binding
- leucine zipper domain binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity