Pbx4 Gene Summary [Mouse]
Enables sequence-specific DNA binding activity. Predicted to be involved in several processes, including embryonic organ development; eye development; and nervous system development. Located in XY body. Is expressed in several structures, including central nervous system; eye; gonad; heart; and urinary system. Orthologous to human PBX4 (PBX homeobox 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pbx4 |
| Official Name | pre B cell leukemia homeobox 4 [Source:MGI Symbol;Acc:MGI:1931321] |
| Ensembl ID | ENSMUSG00000031860 |
| Bio databases IDs | |
| Aliases | pre B cell leukemia homeobox 4 |
| Synonyms | 2410015M21Rik, Edg4, Lpa2, PBX homeobox 4, pre B cell leukaemia homeobox 4, pre B cell leukemia homeobox 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pbx4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- PBC domain
- protein binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- sex chromatin
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pbx4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- eye development
- positive regulation of transcription, DNA-dependent
- embryonic organ development
- brain development
- neuron development
- regulation of transcription from RNA polymerase II promoter
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- XY body
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity