PKNOX2 Gene Summary [Human]
Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009]
Details
| Type | Processed Transcript |
| Official Symbol | PKNOX2 |
| Official Name | PBX/knotted 1 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:16714] |
| Ensembl ID | ENSG00000165495 |
| Bio databases IDs | |
| Aliases | PBX/knotted 1 homeobox 2 |
| Synonyms | D230005H23Rik, LOC100364346, PBX/knotted 1 homeobox 2, PREP2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PKNOX2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- actin monomer binding
- protein binding
- sequence-specific DNA binding
- N-terminal of Homeobox Meis and PKNOX1
- homeodomain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- age-related macular degeneration
- colorectal cancer
- epithelial cancer
- Alzheimer disease
- COVID-19
- alcoholism
- prostate cancer
- prostatic carcinoma
role in cell
- expression in
- invasion by
- migration
- apoptosis
- cell cycle progression
- proliferation
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- Cytoplasm
- actin cytoskeleton
- microtubules
- cytoplasmic bridges
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PKNOX2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- microtubule cytoskeleton
- cytoplasm
- actin cytoskeleton
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- actin monomer binding