PDAP1 Gene Summary [Human]
The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. [provided by RefSeq, Dec 2010]
Details
| Type | Processed Transcript |
| Official Symbol | PDAP1 |
| Official Name | PDGFA associated protein 1 [Source:HGNC Symbol;Acc:HGNC:14634] |
| Ensembl ID | ENSG00000106244 |
| Bio databases IDs | |
| Aliases | PDGFA associated protein 1, PDGF associated protein |
| Synonyms | 28-kDa Heat- and Acid-Stable Phosphoprotein, HASPP28, PAP, PAP1, PDGFA associated protein 1, PDGF Associated |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Casein kinase substrate phosphoprotein PP28
- protein binding
- growth factor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ficolin-1-rich granule lumen
- Extracellular Space
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDAP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding