CWC22 Gene Summary [Human]
Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in cytosol and nuclear speck. Part of U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CWC22 |
| Official Name | CWC22 spliceosome associated protein homolog [Source:HGNC Symbol;Acc:HGNC:29322] |
| Ensembl ID | ENSG00000163510 |
| Bio databases IDs | |
| Aliases | CWC22 spliceosome associated protein homolog, functional spliceosome-associated protein b |
| Synonyms | B230213M24, CWC22 spliceosome-associated protein, CWC22 spliceosome associated protein homolog, EIF4GL, fSAPb, KIAA1604, mKIAA1604, NCM, RGD1565385 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CWC22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MA3 domain
- MIF4G domain
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- cytosol
- spliceosomes
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CWC22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of nuclear mRNA splicing, via spliceosome
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- nuclear speck
- U2-type catalytic step 1 spliceosome
- U2-type catalytic step 2 spliceosome
- cytosol
- spliceosomal complex
- U2-type precatalytic spliceosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding