SNX8 Gene Summary [Human]
Enables identical protein binding activity and phosphatidylinositol binding activity. Involved in early endosome to Golgi transport and intracellular protein transport. Located in early endosome membrane. Colocalizes with retromer complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SNX8 |
| Official Name | sorting nexin 8 [Source:HGNC Symbol;Acc:HGNC:14972] |
| Ensembl ID | ENSG00000106266 |
| Bio databases IDs | |
| Aliases | sorting nexin 8 |
| Synonyms | B130023O14RIK, Mvp1, sorting nexin 8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SNX8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amphipathic helix
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- phosphatidylinositol binding
- PX domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SNX8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- early endosome to Golgi transport
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- intracellular membrane-bounded organelle
- retromer complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- phosphatidylinositol binding