Snx8 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and phosphatidylinositol binding activity. Predicted to be involved in early endosome to Golgi transport and intracellular protein transport. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of retromer complex. Predicted to be active in early endosome membrane. Is expressed in cerebral cortex ventricular layer and small intestine. Orthologous to human SNX8 (sorting nexin 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Snx8 |
| Official Name | sorting nexin 8 [Source:MGI Symbol;Acc:MGI:2443816] |
| Ensembl ID | ENSMUSG00000029560 |
| Bio databases IDs | |
| Aliases | sorting nexin 8 |
| Synonyms | B130023O14RIK, Mvp1, sorting nexin 8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Snx8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amphipathic helix
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- phosphatidylinositol binding
- PX domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Snx8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- early endosome to Golgi transport
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- intracellular membrane-bounded organelle
- retromer complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- phosphatidylinositol binding