RARRES2
RARRES2 Gene Summary
This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014]
Details
| Type | Retained Intron |
| Official Symbol | RARRES2 |
| Official Name | retinoic acid receptor responder 2 [Source:HGNC Symbol;Acc:HGNC:9868] |
| Ensembl ID | ENSG00000106538 |
| Bio databases IDs | |
| Aliases | retinoic acid receptor responder 2, chemerin |
| Synonyms | 0610007L05RIK,CHEMERIN,HP10433,Prochemerin,retinoic acid receptor responder 2,retinoic acid receptor responder (tazarotene induced) 2,TIG2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- receptor binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the RARRES2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TNFSF9
- PPARG
- CCRL2
- CMKLR1
- HLA-DPB1
- NR1H4
- CDKN2D
- TUBB8
disease
- neoplasia
- endometrioma
- peritonitis
- rheumatoid arthritis
- psoriatic arthritis
- metastasis
- diabetes mellitus
- obesity
- breast cancer
- insulin resistance
regulated by
- Immunoglobulin
- ethanol
- insulin
- beta-estradiol
- TNF
- letrozole
- KDM1A
- Ctcflos
- CXCL12
- oleic acid
regulates
- ERK1/2
- Ca2+
- lipid
- IL6
- TNF
- VCAM1
- CD274
- IRS1
- SLC2A4
- IL1B
role in cell
- apoptosis
- binding in
- molecular cleavage in
- expression in
- chemotaxis
- phosphorylation in
- binding
- migration
- production in
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- secretory granule lumen
- cell surface
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the RARRES2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- defense response to Gram-negative bacterium
- insulin receptor signaling pathway
- positive regulation of fat cell differentiation
- chemotaxis
- regulation of lipid catabolic process
- inflammatory response
- retinoid metabolic process
- embryonic digestive tract development
- innate immune response
- positive regulation of protein phosphorylation
- positive regulation of macrophage chemotaxis
- cell differentiation
- positive regulation of chemotaxis
- antifungal humoral response
- defense response to Gram-positive bacterium
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- extracellular matrix
- platelet dense granule lumen
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- receptor binding