FUBP3 Gene Summary [Human]
Enables single-stranded DNA binding activity. Involved in positive regulation of gene expression; positive regulation of transcription, DNA-templated; and transcription, DNA-templated. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | FUBP3 |
| Official Name | far upstream element binding protein 3 [Source:HGNC Symbol;Acc:HGNC:4005] |
| Ensembl ID | ENSG00000107164 |
| Bio databases IDs | |
| Aliases | far upstream element binding protein 3 |
| Synonyms | A330051M14RIK, AV006371, far upstream element binding protein 3, far upstream element (FUSE) binding protein 3, FBP3, LOC158301, Marta2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FUBP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- single-stranded DNA binding
- K homology (KH) RNA-binding domain, type I
- KH domain
- arCOG04150 universal archaeal KH domain protein
- protein binding
- K homology RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- ribosome
- spliceosomes
- nucleoplasm
- perikaryon
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FUBP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular mRNA localization
- transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of gene expression
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- dendritic shaft
- membrane
- neuronal cell body
- ribosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding
- single-stranded DNA binding