FGF9 Gene Summary [Human]
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FGF9 |
| Official Name | fibroblast growth factor 9 [Source:HGNC Symbol;Acc:HGNC:3687] |
| Ensembl ID | ENSG00000102678 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 9, glia-activating factor |
| Synonyms | Eks, Fgf4b, fibroblast growth factor 9, GAF, glia-activating factor, HBFG-9, HBGF-9, SYNS3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FGF9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- FGF core homology domain
- fibroblast growth factor receptor binding
- growth factor
Pathways
Biological processes and signaling networks where the FGF9 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- metastasis
- hepatocellular carcinoma
- hypoxia
- Sjögren syndrome
- prostate cancer
role in cell
- expression in
- phosphorylation in
- proliferation
- development
- apoptosis
- number
- cell death
- survival
- accumulation
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- perinuclear region
- Golgi Apparatus
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FGF9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lung-associated mesenchyme development
- positive regulation of cardiac muscle cell proliferation
- male gonad development
- positive regulation of cell proliferation
- chondrocyte differentiation
- fibroblast growth factor receptor signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- activin receptor signaling pathway
- embryonic limb morphogenesis
- embryonic digestive tract development
- positive regulation of cell division
- angiogenesis
- positive regulation of vascular endothelial growth factor receptor signaling pathway
- positive regulation of activin receptor signaling pathway
- stem cell proliferation
- osteoblast differentiation
- canonical Wnt receptor signaling pathway
- positive regulation of epithelial cell proliferation
- Sertoli cell proliferation
- signal transduction
- cell-cell signaling
- positive regulation of canonical Wnt receptor signaling pathway
- smoothened signaling pathway
- positive regulation of mesenchymal cell proliferation
- positive regulation of MAPK cascade
- embryonic skeletal system development
- cardiac muscle cell proliferation
- substantia nigra development
- organ morphogenesis
- regulation of timing of cell differentiation
- male sex determination
- vascular endothelial growth factor receptor signaling pathway
- eye development
- protein import into nucleus
- positive regulation of gene expression
- positive regulation of stem cell proliferation
- inner ear morphogenesis
- positive regulation of smoothened signaling pathway
- positive regulation of protein phosphorylation
- cell differentiation
- positive regulation of reproductive process
- negative regulation of Wnt receptor signaling pathway
- regulation of cell migration
- mesenchymal cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- heparin binding
- fibroblast growth factor receptor binding