Rgp1 Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in negative regulation of protein catabolic process; positive regulation of GTPase activity; and retrograde transport, endosome to Golgi. Predicted to be located in cytosol and plasma membrane. Predicted to be part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human RGP1 (RGP1 homolog, RAB6A GEF complex partner 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgp1 |
| Official Name | RAB6A GEF compex partner 1 [Source:MGI Symbol;Acc:MGI:1915956] |
| Ensembl ID | ENSMUSG00000028468 |
| Bio databases IDs | |
| Aliases | RAB6A GEF compex partner 1 |
| Synonyms | 1110029E03Rik, F730001J03, KIAA0258, mKIAA0258, RAB6A GEF compex partner 1, RGD1311757, RGP1 homolog, RAB6A GEF complex partner 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rgp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- guanyl-nucleotide exchange factor
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rgp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein catabolic process
- retrograde transport, endosome to Golgi
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- Ric1p-Rgp1p complex
- membrane
- cytosol
- macromolecular complex
- Golgi membrane
- plasma membrane
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity
- small GTPase binding