LHPP Gene Summary [Human]
Enables inorganic diphosphatase activity and protein homodimerization activity. Involved in phosphate-containing compound metabolic process. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | LHPP |
| Official Name | phospholysine phosphohistidine inorganic pyrophosphate phosphatase [Source:HGNC Symbol;Acc:HGNC:30042] |
| Ensembl ID | ENSG00000107902 |
| Bio databases IDs | |
| Aliases | phospholysine phosphohistidine inorganic pyrophosphate phosphatase |
| Synonyms | 2310007H09RIK, HDHD2B, phospholysine phosphohistidine inorganic pyrophosphate phosphatase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LHPP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Haloacid Dehalogenase Superfamily Class (subfamily) IIA
- HAD-superfamily hydrolase, subfamily IIIA
- HAD-hyrolase-like
- phosphoglycolate/pyridoxal phosphate phosphatase family
- phosphatase
- protein homodimerization
- HAD-superfamily subfamily IIA hydrolase, TIGR01458
- protein binding
- inorganic diphosphatase
- Haloacid Dehalogenase-like Hydrolases
- HAD hydrolase, family IA, variant 3
- haloacid dehalogenase-like hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- precursor B-cell acute lymphoblastic leukemia
- neoplasia
- epithelial cancer
- nasopharyngeal carcinoma
- organismal death
- major depression
- glioblastoma
- glioblastoma cancer
- nasopharyngeal cancer
role in cell
- proliferation
- phosphorylation in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LHPP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphate-containing compound metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- cytosol
Molecular Function
What the gene product does at the molecular level
- inorganic diphosphatase activity
- protein binding
- protein homodimerization activity
- metal ion binding
- phosphatase activity