ARPC3 Gene Summary [Human]

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

Details

Type
Protein Coding
Official Symbol
ARPC3
Official Name
actin related protein 2/3 complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:706]
Ensembl ID
ENSG00000111229
Bio databases IDs NCBI: 10094 Ensembl: ENSG00000111229
Aliases actin related protein 2/3 complex subunit 3
Synonyms 1110006A04Rik, actin related protein 2/3 complex subunit 3, actin related protein 2/3 complex, subunit 3, ARC21, Arpc3 predicted, p21-Ar, p21-ARC
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARPC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • actin filament binding
  • structural constituent of cytoskeleton
  • protein binding
  • ARP2/3 complex ARPC3 (21 kDa) subunit

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • diffuse systemic sclerosis
  • infection by Dengue virus 2
regulated by
regulates
  • lipid
  • actin
  • Myelin
  • AMPA receptor
  • zymosan
  • IgG
role in cell
  • survival
  • formation
  • formation in
  • maturation
  • nucleation
  • extension
  • phagocytosis by
  • migration by
  • trafficking
  • maturation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cilia
  • actin cytoskeleton
  • Nucleus
  • actin filaments
  • cytosol
  • nucleoli
  • actin tails
  • cell membrane leading edge
  • clathrin-coated vesicles
  • lamellipodia

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human ARPC3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • regulation of actin filament polymerization
  • Arp2/3 complex-mediated actin nucleation
  • actin polymerization-dependent cell motility

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • extracellular vesicular exosome
  • site of double-strand break
  • focal adhesion
  • membrane
  • actin cytoskeleton
  • cytosol
  • filamentous actin
  • Arp2/3 protein complex
  • lamellipodium

Molecular Function

What the gene product does at the molecular level
  • actin filament binding
  • protein binding
  • structural constituent of cytoskeleton

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.