GLRX3 Gene Summary [Human]
This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | GLRX3 |
| Official Name | glutaredoxin 3 [Source:HGNC Symbol;Acc:HGNC:15987] |
| Ensembl ID | ENSG00000108010 |
| Bio databases IDs | |
| Aliases | glutaredoxin 3, glutaredoxin 4 |
| Synonyms | GLRX4, glutaredoxin 3, GRX3, GRX4, PICOT, TXNL2, TXNL3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GLRX3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- thioredoxin-like domain
- protein kinase C binding
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- protein binding
- identical protein binding
- thioredoxin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
role in cell
- phosphorylation in
- binding in
- interaction in
- hypertrophy
- transactivation in
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cilia
- cell periphery
- Plasma Membrane
- microtubules
- cytosol
- sperm tail
- Z line
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GLRX3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- regulation of the force of heart contraction
- [2Fe-2S] cluster assembly
- negative regulation of cardiac muscle hypertrophy
- cell redox homeostasis
- iron-sulfur cluster assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- Z disc
- cytoplasm
- cell cortex
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- identical protein binding
- protein binding
- RNA binding
- metal ion binding
- iron-sulfur cluster binding