NPPB Gene Summary [Human]
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]
Details
| Type | Protein Coding |
| Official Symbol | NPPB |
| Official Name | natriuretic peptide B [Source:HGNC Symbol;Acc:HGNC:7940] |
| Ensembl ID | ENSG00000120937 |
| Bio databases IDs | |
| Aliases | natriuretic peptide B |
| Synonyms | BNF, BNP, Brain natriuretic peptide, Iso-ANP, Natriuretic factor, natriuretic peptide B, natriuretic peptide type B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NPPB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Atrial natriuretic peptide
- diuretic hormone
- hormone
- protein binding
- receptor binding
Pathways
Biological processes and signaling networks where the NPPB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- stroke
- hepatic fibrosis
- early-onset preeclampsia
- organismal death
- left ventricular hypertrophy
- proteinuria
- septic shock
- acute respiratory distress syndrome
- pancreatic ductal adenocarcinoma
role in cell
- apoptosis
- growth
- binding
- activation
- expression in
- inhibition
- chemotaxis
- proliferation
- differentiation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma membrane fraction
- perinuclear region
- Plasma Membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NPPB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- cGMP biosynthetic process
- cGMP-mediated signaling
- cardiac conduction system development
- negative regulation of systemic arterial blood pressure
- receptor guanylyl cyclase signaling pathway
- cell surface receptor signaling pathway
- regulation of vascular permeability
- vasodilation
- protein folding
- regulation of blood pressure
- body fluid secretion
- neuropeptide signaling pathway
- positive regulation of renal sodium excretion
- negative regulation of cell growth
- positive regulation of urine volume
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- macromolecular complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- hormone activity
- hormone receptor binding
- diuretic hormone activity
- receptor binding