VAT1 Gene Summary [Human]
Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | VAT1 |
| Official Name | vesicle amine transport 1 [Source:HGNC Symbol;Acc:HGNC:16919] |
| Ensembl ID | ENSG00000108828 |
| Bio databases IDs | |
| Aliases | vesicle amine transport 1 |
| Synonyms | VATI, vesicle amine transport 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VAT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- putative NAD(P)H quinone oxidoreductase, PIG3 family
- MDR
- Zinc-binding dehydrogenase
- Alcohol dehydrogenase GroES-like domain
- protein binding
- Enoylreductase
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- azurophil granule lumen
- Extracellular Space
- cellular membrane
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VAT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of mitochondrial fusion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- mitochondrial outer membrane
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- oxidoreductase activity