PHLPP2 Gene Summary [Human]
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in signal transduction. Located in several cellular components, including intercellular bridge; mitotic spindle; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | PHLPP2 |
| Official Name | PH domain and leucine rich repeat protein phosphatase 2 [Source:HGNC Symbol;Acc:HGNC:29149] |
| Ensembl ID | ENSG00000040199 |
| Bio databases IDs | |
| Aliases | PH domain and leucine rich repeat protein phosphatase 2, protein phosphatase, Mg2+/Mn2+ dependent 3B |
| Synonyms | AI481772, C130044A18Rik, PH domain and leucine rich repeat protein phosphatase 2, PHLPPL, PPM3B, RGD1562857 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PHLPP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 1 regulatory subunit 42
- Protein phosphatase 2C
- protein serine/threonine phosphatase
- Ubl1_cv_Nsp3_N-like
- Leucine rich repeat
- enzyme
- protein binding
- Pleckstrin homology-like domain
- Serine/threonine phosphatases, family 2C, catalytic domain
- Leucine Rich repeats (2 copies)
- PP2Cc
Pathways
Biological processes and signaling networks where the PHLPP2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- prostatic carcinoma
- weight loss
- epithelial cancer
- obesity
- prostate cancer
- post-operative acute kidney injury
- lung neoplasm
- hepatic steatosis
- neoplastic cell transformation
role in cell
- binding in
- expression in
- degradation in
- survival
- proliferation
- growth
- colony formation
- invasion by
- phosphorylation in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- cellular membrane
- Nucleus
- cytoplasmic bridges
- cytosol
- nucleoplasm
- photoreceptor outer segments
- photoreceptor inner segments
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PHLPP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- protein dephosphorylation
- hippocampus development
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- mitotic spindle
- cytoplasm
- cytosol
- photoreceptor inner segment
- photoreceptor outer segment membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- metal ion binding
- myosin phosphatase activity