MARCKS Gene Summary [Human]
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MARCKS |
| Official Name | myristoylated alanine rich protein kinase C substrate [Source:HGNC Symbol;Acc:HGNC:6759] |
| Ensembl ID | ENSG00000277443 |
| Bio databases IDs | |
| Aliases | myristoylated alanine rich protein kinase C substrate |
| Synonyms | 80K-L, KINC, LOC294446, LOC681252, MAC, MACS, MARCS, myristoylated alanine rich protein kinase C substrate, PKCSL, PRKCSL |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MARCKS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipopolysaccharide binding domain
- phospholipid binding
- PKC phosphorylation site
- calmodulin binding
- protein kinase C binding
- MARCKS family
- identical protein binding
- effector domain
- phosphorylation site
- actin filament binding
- actin-binding domain
- binding protein
- myristoylation sequence
Pathways
Biological processes and signaling networks where the MARCKS gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- exencephaly
- microcephaly
- neonatal late-onset sepsis
- omphalocele
- diabetes mellitus
- COVID-19
- peripheral arterial disease
- glioblastoma
- glioblastoma cancer
role in cell
- activation in
- migration
- expression in
- apoptosis
- production in
- phosphorylation in
- proliferation
- adhesion
- invasion
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- raft fractions
- soluble fraction
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- cell junction
- cytoskeleton
- organelle
- Cytoplasm
- cilia
- cell surface
- cellular membrane
- focal adhesions
- actin cytoskeleton
- cell cortex
- Nucleus
- centrosome
- Endoplasmic Reticulum
- microtubules
- demarcation membrane systems
- cytosol
- membrane ruffles
- presynaptic membrane
- postsynaptic membrane
- plasma membrane projections
- sister chromatids
- nucleoplasm
- nuclear speckles
- germinal vesicles
- outer dense fibers
- dendritic spines
- growth cone
- membrane blebs
- axon terminals
- dendritic branches
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MARCKS gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural tube development
- actin crosslink formation
- central nervous system development
- apoptotic process
- actin filament organization
- neurogenesis
- actin filament bundle assembly
- mitochondrion organization
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- centrosome
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- cell cortex
- actin filament bundle
- actin cytoskeleton
- germinal vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein kinase C binding
- identical protein binding
- calmodulin binding