Vat1 Gene Summary [Mouse]
Predicted to enable oxidoreductase activity and zinc ion binding activity. Predicted to be involved in negative regulation of mitochondrial fusion. Predicted to be active in mitochondrial outer membrane. Is expressed in brain. Orthologous to human VAT1 (vesicle amine transport 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vat1 |
| Official Name | vesicle amine transport 1 [Source:MGI Symbol;Acc:MGI:1349450] |
| Ensembl ID | ENSMUSG00000034993 |
| Bio databases IDs | |
| Aliases | vesicle amine transport 1 |
| Synonyms | VATI, vesicle amine transport 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- putative NAD(P)H quinone oxidoreductase, PIG3 family
- MDR
- Zinc-binding dehydrogenase
- Alcohol dehydrogenase GroES-like domain
- protein binding
- Enoylreductase
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- azurophil granule lumen
- Extracellular Space
- cellular membrane
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of mitochondrial fusion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- mitochondrial outer membrane
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- oxidoreductase activity