TMEM33 Gene Summary [Human]
Involved in positive regulation of endoplasmic reticulum unfolded protein response; regulation of endoplasmic reticulum tubular network organization; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane; melanosome; and nuclear envelope. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TMEM33 |
| Official Name | transmembrane protein 33 [Source:HGNC Symbol;Acc:HGNC:25541] |
| Ensembl ID | ENSG00000109133 |
| Bio databases IDs | |
| Aliases | transmembrane protein 33 |
| Synonyms | 1110006G02RIK, 1600019D15Rik, 2410089A21Rik, 2700052H22Rik, 5430406L04Rik, DB83, Pom33, SHINC-3, Transmembrane protein 33 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMEM33 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Transmembrane protein 33/Nucleoporin POM33
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nuclear envelope
- melanosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TMEM33 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane organization
- innate immune response
- endoplasmic reticulum tubular network organization
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear envelope
- melanosome
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding