UGT2B10 Gene Summary [Human]
Predicted to be involved in lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | UGT2B10 |
| Official Name | UDP glucuronosyltransferase family 2 member B10 [Source:HGNC Symbol;Acc:HGNC:12544] |
| Ensembl ID | ENSG00000109181 |
| Bio databases IDs | |
| Aliases | UDP glucuronosyltransferase family 2 member B10 |
| Synonyms | UDP glucuronosyltransferase family 2 member B10, UDPGT, UDPGT2B10 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UGT2B10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycosyltransferase family 1 and related proteins with GTB topology
- glycosyltransferase, MGT family
- enzyme
- UDP-glucoronosyl and UDP-glucosyl transferase
- glucuronosyltransferase
Pathways
Biological processes and signaling networks where the UGT2B10 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- progressive familial intrahepatic cholestasis type 1
regulates
- lipid
- 13-hydroxyoctadecadienoic acid
- nicotine-glucuronide
- 12-hydroxyeicosatetraenoic acid
- 15-hydroxyeicosatetraenoic acid
- 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanol
- NNAL-N-glucuronide
- cotinine-glucuronide
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UGT2B10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- estrogen metabolic process
- cellular glucuronidation
- lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- UDP-glycosyltransferase activity
- glucuronosyltransferase activity