SPACA3 Gene Summary [Human]

The protein encoded by this gene is a sperm surface protein that may be involved in adhesion to the egg prior to fertilization. While the encoded protein has significant similarity to lysozyme at the amino acid level, it has no detectable bacteriocidal activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Details

Type
Protein Coding
Official Symbol
SPACA3
Official Name
sperm acrosome associated 3 [Source:HGNC Symbol;Acc:HGNC:16260]
Ensembl ID
ENSG00000141316
Bio databases IDs NCBI: 124912 Ensembl: ENSG00000141316
Aliases sperm acrosome associated 3, cancer/testis antigen 54, sperm lyzozyme-like acrosomal protein 1
Synonyms 1700025M08RIK, ALLP17, CT54, LYC3, LYZC, LYZL3, mSLLP1, SLLP1, sperm acrosome associated 3
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPACA3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein binding
  • lysozyme-like domains

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • acute myeloid leukemia
  • chronic lymphocytic leukemia
  • plasma cell myeloma
  • chronic myeloid leukemia
regulated by
  • diphtheria toxin
regulates
role in cell
  • activation
  • phagocytosis by
  • molecular cleavage in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • acrosome
  • secretory granules

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human SPACA3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • sperm-egg recognition
  • positive regulation of macrophage activation
  • fusion of sperm to egg plasma membrane
  • positive regulation of phagocytosis
  • monocyte activation

Cellular Component

Where in the cell the gene product is active
  • acrosomal membrane
  • acrosomal vesicle
  • secretory granule
  • sperm flagellum
  • extracellular region
  • acrosomal matrix

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • lysozyme activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.