KLF10 Gene Summary [Human]
This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Details
| Type | Protein Coding |
| Official Symbol | KLF10 |
| Official Name | Kruppel like factor 10 [Source:HGNC Symbol;Acc:HGNC:11810] |
| Ensembl ID | ENSG00000155090 |
| Bio databases IDs | |
| Aliases | Kruppel like factor 10, KLF transcription factor 10, early growth response alpha |
| Synonyms | EGRA, EGR[a], EGRAL, EGR-alpha, EGR-α, GC binding, Gdnfif, KLF transcription factor 10, Kruppel-like transcription factor 10, mGIF, TGF beta INDUCIBLE EARLY GROWTH RESPONSE, TGFB INDUCIBLE EARLY, TGF β INDUCIBLE EARLY GROWTH RESPONSE, TIEG, TIEG-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLF10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- DNA binding domain
- nucleic acid binding
- protein binding
- N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins
- sequence-specific DNA binding
- C2H2-type zinc ribbon
- C2H2-type zinc finger
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- transcription repression domain
- double-stranded DNA binding
- Zinc-finger double domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- neoplasia
- cancer
- breast cancer
- epithelial cancer
- epithelial neoplasia
- cervical cancer
- abdominal cancer
- digestive system cancer
role in cell
- binding in
- expression in
- quantity
- proliferation
- growth
- invasion by
- differentiation
- apoptosis
- G1 phase
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLF10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bone mineralization
- negative regulation of cell proliferation
- cell-cell signaling
- cellular response to starvation
- circadian rhythm
- positive regulation of transcription from RNA polymerase II promoter
- regulation of circadian rhythm
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoclast differentiation
- negative regulation of transcription, DNA-dependent
- somatic stem cell maintenance
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- core promoter sequence-specific DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity