RAB3IP Gene Summary [Human]
Enables guanyl-nucleotide exchange factor activity and identical protein binding activity. Involved in cilium assembly; protein localization to organelle; and protein targeting to membrane. Located in centrosome; cytosol; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RAB3IP |
| Official Name | RAB3A interacting protein [Source:HGNC Symbol;Acc:HGNC:16508] |
| Ensembl ID | ENSG00000127328 |
| Bio databases IDs | |
| Aliases | RAB3A interacting protein, rabin3 |
| Synonyms | B230311A06, FLJ22548, GTPAT12, RAB3A interacting protein, RABIN3, RABIN8, Rn8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAB3IP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab11BD_RAB3IP_like
- DivIVA protein
- Ezrin/radixin/moesin, alpha-helical domain
- prefoldin
- guanyl-nucleotide exchange factor
- enzyme binding
- protein binding
- TATA element modulatory factor 1 TATA binding
- identical protein binding
- GDP/GTP exchange factor Sec2p
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- small cell lung cancer
role in cell
- assembly
- ciliogenesis in
- autoinhibition in
- polarization
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- basal bodies
- centrosome
- cytosol
- membrane ruffles
- nucleoplasm
- dendrite initial segments
- cellular protrusions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAB3IP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- protein transport
- negative regulation of filopodium assembly
- positive regulation of flagellum assembly
- exocytosis
- protein targeting to membrane
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- Golgi to plasma membrane transport vesicle
- perinuclear region of cytoplasm
- cytosol
- trans-Golgi network membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase binding
- guanyl-nucleotide exchange factor activity