PRMT8 Gene Summary [Human]
Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | PRMT8 |
| Official Name | protein arginine methyltransferase 8 [Source:HGNC Symbol;Acc:HGNC:5188] |
| Ensembl ID | ENSG00000111218 |
| Bio databases IDs | |
| Aliases | protein arginine methyltransferase 8 |
| Synonyms | HRMT1L3, HRMT1L4, LOC683275, protein arginine methyltransferase 8, protein arginine N-methyltransferase 8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRMT8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit
- enzyme binding
- enzyme
- protein binding
- AdoMet_MTases
- protein-arginine N-methyltransferase
- S-adenosylmethionine-dependent methyltransferase
- identical protein binding
- methyltransferase domain
- methyltransferase
- histone methyltransferase
- binding protein
- protein homodimerization
Pathways
Biological processes and signaling networks where the PRMT8 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pelvic organ prolapse
- hyperactive behavior
- restless legs syndrome
- gait disturbance
- pneumonia
role in cell
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- postsynaptic region
- cell cortex
- Plasma Membrane
- cytoplasmic face of plasma membrane
- dendritic spines
- synaptosomes
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRMT8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
- protein homooligomerization
- protein methylation
- peptidyl-arginine methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein-arginine omega-N asymmetric methyltransferase activity
- identical protein binding
- protein binding
- protein homodimerization activity
- histone methyltransferase activity
- protein-arginine omega-N monomethyltransferase activity
- S-adenosylmethionine-dependent methyltransferase activity
- enzyme binding