SYNCRIP Gene Summary [Human]
This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011]
Details
| Type | Protein Coding |
| Official Symbol | SYNCRIP |
| Official Name | synaptotagmin binding cytoplasmic RNA interacting protein [Source:HGNC Symbol;Acc:HGNC:16918] |
| Ensembl ID | ENSG00000135316 |
| Bio databases IDs | |
| Aliases | synaptotagmin binding cytoplasmic RNA interacting protein, heterogeneous nuclear ribonucleoprotein Q |
| Synonyms | 2610109K23Rik, 4632417O19Rik, Ab2-339, GRY-RBP, HNRNPQ, HNRPQ, HNRPQ1, LOC100910033, NS1-associated protein 1, NSAP1, Nsap1l, PP68, synaptotagmin binding cytoplasmic RNA interacting protein, synaptotagmin binding, cytoplasmic RNA interacting protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SYNCRIP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- RGG domain
- RNA recognition motif (RRM) superfamily
- mRNA 3' UTR binding
- mRNA 5' UTR binding
- RNA recognition motif
- Heterogeneous nuclear ribonucleoprotein Q acidic domain
- poly(A) binding protein
- protein binding
- heterogeneous nuclear ribonucleoprotein R, Q family
- NURR (N-terminal unit for RNA recognition) domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- psoriasis
- pervasive developmental disorder
- tumorigenesis
- preeclampsia
- plexiform neurofibroma
role in cell
- growth
- production in
- expression in
- migration
- apoptosis
- phosphorylation in
- repression in
- quantity
- mesenchymal epithelial transition
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microsomal fraction
- nuclear fraction
- detergent-insoluble fractions
- polyribosome fractions
- glutaminergic synapse
- endoplasmic reticulum mitochondria contact site
- catalytic step 2 spliceosome
- Cytoplasm
- cell surface
- ribosome
- polysomes
- cytosol
- spliceosomes
- nucleoplasm
- dendrite initial segments
- perikaryon
- postsynaptic density
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SYNCRIP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- positive regulation of cytoplasmic translation
- negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- osteoblast differentiation
- RNA processing
- cellular response to interferon-gamma
- CRD-mediated mRNA stabilization
- negative regulation of translation
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- CRD-mediated mRNA stability complex
- nucleus
- catalytic step 2 spliceosome
- membrane
- histone pre-mRNA 3'end processing complex
- cytosol
- endoplasmic reticulum
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA 5'-UTR binding