FEV Gene Summary [Human]
This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FEV |
| Official Name | FEV transcription factor, ETS family member [Source:HGNC Symbol;Acc:HGNC:18562] |
| Ensembl ID | ENSG00000163497 |
| Bio databases IDs | |
| Aliases | FEV transcription factor, ETS family member |
| Synonyms | FEV transcription factor, ETS family member, HSRNAFEV, mPet-1, PET-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FEV often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Ets-domain
- sequence-specific DNA binding
- transcription factor activity
- alanine-rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- colorectal cancer
- MYCN amplification negative neuroblastoma
- neuroblastoma formation
- MYCN amplification positive aggressive neuroblastoma
- neuroblastoma
regulated by
role in cell
- expression in
- number
- growth
- differentiation
- maturation
- excitability
- signaling in
- CSN5i-3 sensitivity
- abnormal morphology
- specification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear speckles
- chromatin
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FEV gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron fate specification
- positive regulation of gene expression
- cell differentiation
- neuron maturation
- positive regulation of transcription from RNA polymerase II promoter
- maternal behavior
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity