AKAP3
AKAP3 Gene Summary
This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is reported to participate in protein-protein interactions with the R-subunit of the protein kinase A as well as sperm-associated proteins. This protein is expressed in spermatozoa and localized to the acrosomal region of the sperm head as well as the length of the principal piece. It may function as a regulator of motility, capacitation, and the acrosome reaction. [provided by RefSeq, May 2013]
Details
| Type | Protein Coding |
| Official Symbol | AKAP3 |
| Official Name | A-kinase anchoring protein 3 [Source:HGNC Symbol;Acc:HGNC:373] |
| Ensembl ID | ENSG00000111254 |
| Bio databases IDs | |
| Aliases | A-kinase anchoring protein 3, Fibrous Sheath Protein of 95 kDa, cancer/testis antigen 82 |
| Synonyms | AKAP 110,A-kinase anchoring protein 3,A kinase anchor protein 3,CT82,FSP95,HEL159,PRKA3,SOB1,SPGF82 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase A binding
- amphipathic helix
- RII binding domain
- protein binding
- A-kinase anchor protein 110 kDa (AKAP 110)
Pathways
Biological processes and signaling networks where the AKAP3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ROPN1
- ROPN1L
- PRKAR2A
- PRKAR1A
- BRAP
- AKAP4
- PRKACA
- PHLPP1
- GNA13
- ANKRD26
disease
- spermatogenic failure 82
- ovarian cancer
regulated by
- PKA RII
- FADS2
- sperm
- STK33
- myoblasts
- FIGLA
- diphtheria toxin
- OSM
- FBXO44
regulates
role in cell
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- flagella
- sperm midpiece
- sperm tail
- acrosome
- sperm fibrous sheath
- pseudopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the AKAP3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- acrosome reaction
- blastocyst hatching
- protein localization
- transmembrane receptor protein serine/threonine kinase signaling pathway
- single fertilization
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- sperm midpiece
- cytoplasm
- acrosomal vesicle
- sperm principal piece
- flagellar fibrous sheath
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- protein kinase A binding