ANKRD26 Gene Summary [Human]
This gene encodes a protein containing N-terminal ankyrin repeats which function in protein-protein interactions. Mutations in this gene are associated with autosomal dominant thrombocytopenia-2. Pseudogenes of this gene are found on chromosome 7, 10, 13 and 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | ANKRD26 |
| Official Name | ankyrin repeat domain 26 [Source:HGNC Symbol;Acc:HGNC:29186] |
| Ensembl ID | ENSG00000107890 |
| Bio databases IDs | |
| Aliases | ankyrin repeat domain 26, ankyrin repeat domain containing 26 |
| Synonyms | 5730521P14RIK, ankyrin repeat domain containing 26, bA145E8.1, BC008111, LOC101929149, LOC102724218, THC2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ANKRD26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- SPEC
- Crescentin protein
- chromosome segregation protein SMC, primarily archaeal type
- transcription regulator
- Ankyrin repeats (many copies)
- exonuclease SbcC
- Ciliary protein causing Leber congenital amaurosis disease
- CCDC144C protein coiled-coil region
- rad50
- Synaptonemal complex protein 1 (SCP-1)
- Domain of unknown function (DUF3496)
- Ankyrin repeats (3 copies)
- Myosin tail
- helix-rich Mycoplasma protein
- protein binding
- Ankyrin repeat
- Alpha helical coiled-coil rod protein (HCR)
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- RIM-binding protein of the cytomatrix active zone
- Centrosomal protein of 63 kDa
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- detergent resistant lipid raft fraction
- centrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ANKRD26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fat cell differentiation
Cellular Component
Where in the cell the gene product is active
- centrosome
Molecular Function
What the gene product does at the molecular level
- protein binding