Akap3

Predicted to enable protein kinase A binding activity. Predicted to be involved in establishment of protein localization and flagellated sperm motility. Predicted to act upstream of or within blastocyst hatching and cell surface receptor protein serine/threonine kinase signaling pathway. Predicted to be located in acrosomal vesicle and sperm midpiece. Predicted to be active in cytoplasm; sperm fibrous sheath; and sperm principal piece. Human ortholog(s) of this gene implicated in spermatogenic failure 82. Orthologous to human AKAP3 (A-kinase anchoring protein 3). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Akap3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Akap3 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Akap3 gene, providing context for its role in the cell.