Akap3 Gene Summary [Mouse]
Enables protein kinase A binding activity. Involved in establishment of protein localization and flagellated sperm motility. Acts upstream of or within blastocyst hatching; cell surface receptor protein serine/threonine kinase signaling pathway; and protein localization. Located in acrosomal vesicle and sperm principal piece. Is active in sperm fibrous sheath. Is expressed in early conceptus; secondary oocyte; and spermatocyte. Human ortholog(s) of this gene implicated in spermatogenic failure 82. Orthologous to human AKAP3 (A-kinase anchoring protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akap3 |
| Official Name | A kinase (PRKA) anchor protein 3 [Source:MGI Symbol;Acc:MGI:1341149] |
| Ensembl ID | ENSMUSG00000030344 |
| Bio databases IDs | |
| Aliases | A kinase (PRKA) anchor protein 3 |
| Synonyms | AKAP 110, A-kinase anchoring protein 3, A kinase anchor protein 3, CT82, FSP95, HEL159, PRKA3, SOB1, SPGF82 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Akap3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase A binding
- amphipathic helix
- RII binding domain
- protein binding
- A-kinase anchor protein 110 kDa (AKAP 110)
Pathways
Biological processes and signaling networks where the Akap3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- flagella
- sperm midpiece
- sperm tail
- acrosome
- sperm fibrous sheath
- pseudopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Akap3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acrosome reaction
- blastocyst hatching
- protein localization
- transmembrane receptor protein serine/threonine kinase signaling pathway
- single fertilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- sperm midpiece
- cytoplasm
- acrosomal vesicle
- sperm principal piece
- flagellar fibrous sheath
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein kinase A binding