CAPZA2 Gene Summary [Human]
The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CAPZA2 |
| Official Name | capping actin protein of muscle Z-line subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:1490] |
| Ensembl ID | ENSG00000198898 |
| Bio databases IDs | |
| Aliases | capping actin protein of muscle Z-line subunit alpha 2, F-actin capping protein alpha-2 subunit |
| Synonyms | 1110053K06RIK, CAPPA2, capping actin protein of muscle Z-line subunit alpha 2, capping actin protein of muscle Z-line subunit α 2, Capping Protein alpha2, Capping protein α 2, CAPZ, Capz Alpha2, Caza2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CAPZA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-actin capping protein alpha subunit
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cortical cytoskeleton
- Extracellular Space
- cellular membrane
- actin cytoskeleton
- Mitochondria
- cytosol
- dendritic spines
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CAPZA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- barbed-end actin filament capping
- macromolecular complex assembly
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- brush border
- membrane
- actin cytoskeleton
- cytosol
- extracellular region
- F-actin capping protein complex
- cortical cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding