Cnot2 Gene Summary [Mouse]
Predicted to enable transcription corepressor binding activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Involved in regulation of stem cell population maintenance and trophectodermal cell differentiation. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of CCR4-NOT core complex. Predicted to be active in P-body. Is expressed in several structures, including 1st branchial arch; brain; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human CNOT2 (CCR4-NOT transcription complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cnot2 |
| Official Name | CCR4-NOT transcription complex, subunit 2 [Source:MGI Symbol;Acc:MGI:1919318] |
| Ensembl ID | ENSMUSG00000020166 |
| Bio databases IDs | |
| Aliases | CCR4-NOT transcription complex, subunit 2 |
| Synonyms | 2600016M12Rik, 2810470K03RIK, CCR4-NOT transcription complex subunit 2, CCR4-NOT transcription complex, subunit 2, CDC36, HSPC131, IDNADFS, LOC100128679, NOT2, NOT2H |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cnot2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- NOT2 / NOT3 / NOT5 family
- poly(A)-specific ribonuclease
- transcription cofactor
- transcription factor binding
- protein binding
- NOT-box domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- intellectual developmental disorder with nasal speech, dysmorphic facies, and variable skeletal anomalies
- neurodevelopmental disorder
- breast cancer
- ovarian carcinoma
- epithelial ovarian cancer
- amyotrophic lateral sclerosis
- tumorigenesis
regulated by
regulates
- reporter gene
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
role in cell
- apoptosis
- assembly
- growth
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cnot2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of translation
- positive regulation of cytoplasmic mRNA processing body assembly
- regulation of stem cell maintenance
- gene silencing by RNA
- negative regulation of intracellular estrogen receptor signaling pathway
- trophectodermal cell differentiation
- nuclear-transcribed mRNA poly(A) tail shortening
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- cytoplasmic mRNA processing body
- cytosol
- CCR4-NOT core complex
- CCR4-NOT complex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- poly(A)-specific ribonuclease activity
- transcription cofactor activity
- protein binding