APOBEC1 Gene Summary [Human]
This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]
Details
| Type | Protein Coding |
| Official Symbol | APOBEC1 |
| Official Name | apolipoprotein B mRNA editing enzyme catalytic subunit 1 [Source:HGNC Symbol;Acc:HGNC:604] |
| Ensembl ID | ENSG00000111701 |
| Bio databases IDs | |
| Aliases | apolipoprotein B mRNA editing enzyme catalytic subunit 1 |
| Synonyms | APO1, apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1, apolipoprotein B mRNA editing enzyme catalytic subunit 1, BEDP, CDAR1, HEPR, REPR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human APOBEC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- APOBEC2
- cytidine_deaminase-like
- leucine rich domain
- mRNA binding
- APOBEC-like N-terminal domain
- protein domain specific binding
- enzyme
- protein binding
- APOBEC4-like -AID/APOBEC-deaminase
- APOBEC1
- enzyme activator activity
- Secreted Novel AID/APOBEC-like Deaminase 4
- mRNA 3' UTR binding
- zinc ion binding
- cytidine deaminase
- Novel AID APOBEC clade 2
- ribonucleoprotein binding
- Novel AID APOBEC clade 1
- APOBEC4
- basic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- Alzheimer disease
- pituitary gland adenoma
- head and neck neuroendocrine neoplasia
role in cell
- synthesis in
- proliferation
- quantity
- secretion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human APOBEC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- triglyceride metabolic process
- cytidine deamination
- mRNA processing
- hypomethylation of CpG island
- lipoprotein biosynthetic process
- regulation of cell proliferation
- lipoprotein transport
- lipid metabolic process
- mRNA stabilization
- establishment of localization in cell
- negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- negative regulation of triglyceride metabolic process
- response to gamma radiation
- cytidine to uridine editing
- mRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- mRNA editing complex
- cytoplasm
- apolipoprotein B mRNA editing enzyme complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- RNA binding
- protein binding
- mRNA 3'-UTR AU-rich region binding
- cytidine deaminase activity