Apobec1 Gene Summary [Mouse]
Enables mRNA 3'-UTR AU-rich region binding activity. Involved in cytidine to uridine editing and positive regulation of gene expression via chromosomal CpG island demethylation. Acts upstream of or within several processes, including lipoprotein transport; negative regulation of metabolic process; and response to gamma radiation. Predicted to be part of apolipoprotein B mRNA editing enzyme complex. Predicted to be active in cytoplasm and nucleus. Is expressed in early conceptus; genitourinary system; and liver. Orthologous to human APOBEC1 (apolipoprotein B mRNA editing enzyme catalytic subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apobec1 |
| Official Name | apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 [Source:MGI Symbol;Acc:MGI:103298] |
| Ensembl ID | ENSMUSG00000040613 |
| Bio databases IDs | |
| Aliases | apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 |
| Synonyms | APO1, apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1, apolipoprotein B mRNA editing enzyme catalytic subunit 1, BEDP, CDAR1, HEPR, REPR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Apobec1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- APOBEC2
- cytidine_deaminase-like
- leucine rich domain
- mRNA binding
- APOBEC-like N-terminal domain
- protein domain specific binding
- enzyme
- protein binding
- APOBEC4-like -AID/APOBEC-deaminase
- APOBEC1
- enzyme activator activity
- Secreted Novel AID/APOBEC-like Deaminase 4
- mRNA 3' UTR binding
- zinc ion binding
- cytidine deaminase
- Novel AID APOBEC clade 2
- ribonucleoprotein binding
- Novel AID APOBEC clade 1
- APOBEC4
- basic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- Alzheimer disease
- pituitary gland adenoma
- head and neck neuroendocrine neoplasia
role in cell
- synthesis in
- proliferation
- quantity
- secretion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Apobec1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- triglyceride metabolic process
- cytidine deamination
- mRNA processing
- hypomethylation of CpG island
- lipoprotein biosynthetic process
- regulation of cell proliferation
- lipoprotein transport
- lipid metabolic process
- mRNA stabilization
- establishment of localization in cell
- negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- negative regulation of triglyceride metabolic process
- response to gamma radiation
- cytidine to uridine editing
- mRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- mRNA editing complex
- cytoplasm
- apolipoprotein B mRNA editing enzyme complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- RNA binding
- protein binding
- mRNA 3'-UTR AU-rich region binding
- cytidine deaminase activity