RNGTT Gene Summary [Human]
Enables mRNA guanylyltransferase activity and triphosphatase activity. Involved in 7-methylguanosine mRNA capping. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RNGTT |
| Official Name | RNA guanylyltransferase and 5'-phosphatase [Source:HGNC Symbol;Acc:HGNC:10073] |
| Ensembl ID | ENSG00000111880 |
| Bio databases IDs | |
| Aliases | RNA guanylyltransferase and 5'-phosphatase |
| Synonyms | CAP1A, CAPPING ENZYME, hCAP, HCE, HCE1, MCE1, RNA guanylyltransferase and 5'-phosphatase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNGTT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- guanylyltransferase domain
- triphosphatase domain
- RNA 5' triphosphatase domain
- triphosphatase
- PTP_DSP_cys
- protein binding
- Dual specificity phosphatase, catalytic domain
- mRNA capping enzyme, C-terminal domain
- Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases
- phosphatase
- polynucleotide 5'-phosphatase
- RNA guanylyltransferase
- mRNA guanylyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- endometrium tumor
- myopathy
regulates
- heteroduplex
role in cell
- survival
- capping in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNGTT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA capping
- RNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- phosphoprotein phosphatase activity
- ATP binding
- triphosphatase activity
- protein binding
- RNA guanylyltransferase activity
- mRNA guanylyltransferase activity
- polynucleotide 5'-phosphatase activity