NFATC2 Gene Summary [Human]
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]
Details
| Type | Protein Coding |
| Official Symbol | NFATC2 |
| Official Name | nuclear factor of activated T cells 2 [Source:HGNC Symbol;Acc:HGNC:7776] |
| Ensembl ID | ENSG00000101096 |
| Bio databases IDs | |
| Aliases | nuclear factor of activated T cells 2 |
| Synonyms | AI607462, JCOSL, NFAT1, NFAT1-D, NF-ATp, nuclear factor of activated T-cells 2, nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NFATC2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SP repeat domain
- protein interaction domain
- transcription regulator
- regulatory domain
- Rel homology dimerization domain
- transcription activation domain
- transcription factor binding
- chromatin binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Caspase 3 cleavage site
- NFAT homology region
- phosphatase binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- DNA binding domain
- nucleic acid binding
- IPT
- nuclear localization sequence
- SRR-1 motif
- protein binding
- calcineurin-binding domain
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- IPT/TIG domain
- N-terminal sub-domain of the Rel homology domain (RHD)
- CAD domain
- transcription factor activity
- Casein kinase I binding site
Pathways
Biological processes and signaling networks where the NFATC2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- April Mediated Signaling
- B Cell Activating Factor Signaling
- Calcium Signaling
- Calcium-induced T Lymphocyte Apoptosis
- fMLP Signaling in Neutrophils
- Glucocorticoid Receptor Signaling
- Gαq Signaling
- IL-12 Signaling and Production in Macrophages
- Natural Killer Cell Signaling
- Netrin Signaling
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Protein Kinase A Signaling
- RANK Signaling in Osteoclasts
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Systemic Lupus Erythematosus Signaling
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th17 Activation Pathway
- Th2 Pathway
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- experimental autoimmune encephalomyelitis
- cancer
- non-insulin-dependent diabetes mellitus
- cardiovascular disorder
- neoplasia
- allergy
- organismal death
role in cell
- proliferation
- binding
- expression in
- activation in
- growth
- migration
- production in
- apoptosis
- quantity
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NFATC2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcineurin-NFAT signaling cascade
- transcription from RNA polymerase II promoter
- regulation of transcription, DNA-dependent
- response to xenobiotic stimulus
- positive regulation of transcription from RNA polymerase II promoter
- response to DNA damage stimulus
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to calcium ion
- positive regulation of transcription, DNA-dependent
- positive regulation of gene expression
- myotube cell development
- positive regulation of B cell proliferation
- cytokine production
- cell migration
- cartilage development
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- cytoplasm
- AP1 complex
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- chromatin binding
- transcription factor binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- 14-3-3 protein binding
- binding, bridging