Rngtt Gene Summary [Mouse]
Predicted to enable inorganic triphosphate phosphatase activity and mRNA guanylyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to be located in nucleus. Is expressed in several structures, including heart; liver; lung; metanephros; and spleen. Orthologous to human RNGTT (RNA guanylyltransferase and 5'-phosphatase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rngtt |
| Official Name | RNA guanylyltransferase and 5'-phosphatase [Source:MGI Symbol;Acc:MGI:1329041] |
| Ensembl ID | ENSMUSG00000028274 |
| Bio databases IDs | |
| Aliases | RNA guanylyltransferase and 5'-phosphatase |
| Synonyms | CAP1A, CAPPING ENZYME, hCAP, HCE, HCE1, MCE1, RNA guanylyltransferase and 5'-phosphatase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rngtt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- guanylyltransferase domain
- triphosphatase domain
- RNA 5' triphosphatase domain
- triphosphatase
- PTP_DSP_cys
- protein binding
- Dual specificity phosphatase, catalytic domain
- mRNA capping enzyme, C-terminal domain
- Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases
- phosphatase
- polynucleotide 5'-phosphatase
- RNA guanylyltransferase
- mRNA guanylyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- endometrium tumor
- myopathy
regulated by
- beta-estradiol
- iodoacetic acid
- onalespib
- tetrachlorodibenzodioxin
- EIF4E
- camptothecin
- vanadate
- GnRH analog
- SUPT5H
- magnesium
regulates
- heteroduplex
role in cell
- survival
- capping in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rngtt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA capping
- RNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- phosphoprotein phosphatase activity
- ATP binding
- triphosphatase activity
- protein binding
- RNA guanylyltransferase activity
- mRNA guanylyltransferase activity
- polynucleotide 5'-phosphatase activity